群馬大学生 体調節研究所 代謝システム制御分野 服部研究室群馬大学生 体調節研究所 代謝システム制御分野 服部研究室

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主要論文（原著）Selected Publications

  1. Mori Y, Akizuki Y, Honda R, Takao M, Tsuchimoto A, Hashimoto S, Iio H, Kato M, Kaiho-Soma A, Saeki Y, Hamazaki J, Murata S, Ushijima T, Hattori N, Ohtake F. Intrinsic signaling pathways modulate targeted protein degradation. Nat Commun 15(1):5379 (2024) doi: 10.1038/s41467-024-49519-z
  2. Yamamoto Y, Watanabe T, Ureshino H, Kurahashi Y, Fukuda-Kurahashi Y, Kamachi K, Kawasoe K, Kidoguchi K, Yamashita S, Hattori N, Ushijima T, Kimura S. DNA demethylating agents for chemoprevention of oncovirus-associated leukemogenesis. Leukemia 38(7):1613-1616 (2024) doi: 10.1038/s41375-024-02299-3
  3. Okunishi K*, Kochi Y, Zhao M, Wang H, Nakagome K, Izumi T*. Munc13-4 regulates asthma and obesity in mice by controlling functions of CD11c(+) antigen-presenting cells. Allergy 79(7):1992-1995 (2024)(*Corresponding author) doi: 10.1111/all.16087
  4. Zhao M#, Okunishi K#, Bu Y#, Kikuchi O, Wang H, Kitamura T, Izumi T. Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders. JCI Insight 8(4): (2023)(#Equally contributed) doi: 10.1172/jci.insight.161229
  5. Zhao K, Matsunaga K, Mizuno K, Wang H, Okunishi K, Izumi T. Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis. Elife 12((2023) doi: 10.7554/eLife.82821
  6. Yamashiro Y, Ramirez K, Nagayama K, Hattori N, Liu YY, Matsunaga S, Tomita S, Kubota Y, Yanagisawa H. Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation. Cardiovasc Res 119(7):1606-1618 (2023) doi: 10.1093/cvr/cvac190
  7. Shimomura K, Hattori N, Iida N, Muranaka Y, Sato K, Shiraishi Y, Arai Y, Hama N, Shibata T, Narushima D, Kato M, Takamaru H, Okamoto K, Takeda H. Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development. Nat Commun 14(1):6514 (2023) doi: 10.1038/s41467-023-42228-z
  8. Nishiyama K, Nishinakamura H, Takeshima H, Yuyu L, Takeuchi C, Hattori N, Takeda H, Yamashita S, Wakabayashi M, Sato K, Obama K, Ushijima T. Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples. PLoS One 18(10):e0290034 (2023) doi: 10.1371/journal.pone.0290034
  9. Kurahashi Y, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Yamashita S, Hattori N, Nakamura H, Kawaguchi A, Ushijima T, Sueoka E, Kimura S. Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL. Blood Adv 7(8):1545-1559 (2023) doi: 10.1182/bloodadvances.2022008362
  10. Hattori N, Liu YY, Ushijima T. DNA Methylation Analysis. Methods Mol Biol 2691(165-183 (2023) doi: 10.1007/978-1-0716-3331-1_13
  11. Arai N, Hattori N, Yamashita S, Liu YY, Ebata T, Takeuchi C, Takeshima H, Fujii S, Kondo H, Mukai H, Ushijima T. HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity. Breast Cancer Res Treat 201(2):317-328 (2023) doi: 10.1007/s10549-023-07013-y
  12. Zhang CD, Takeshima H, Sekine S, Yamashita S, Liu YY, Hattori N, Abe H, Yamashita H, Fukuda M, Imamura Y, Ushiku T, Katai H, Makino H, Watanabe M, Seto Y, Ushijima T. Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation. Gastric Cancer 25(2):336-345 (2022) doi: 10.1007/s10120-021-01252-y
  13. Yamada H, Takeshima H, Fujiki R, Yamashita S, Sekine S, Ando T, Hattori N, Okabe A, Yoshikawa T, Obama K, Katai H, Kaneda A, Ushijima T. ARID1A loss-of-function induces CpG island methylator phenotype. Cancer Lett 532(215587 (2022) doi: 10.1016/j.canlet.2022.215587
  14. Ueda S, Yamashita S, Nakajima M, Kumamoto T, Ogawa C, Liu YY, Yamada H, Kubo E, Hattori N, Takeshima H, Wakabayashi M, Iida N, Shiraishi Y, Noguchi M, Sato Y, Ushijima T. A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy. Proc Natl Acad Sci U S A 119(31):e2123241119 (2022) doi: 10.1073/pnas.2123241119
  15. Yasukawa Y, Hattori N, Iida N, Takeshima H, Maeda M, Kiyono T, Sekine S, Seto Y, Ushijima T. SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation. Carcinogenesis 42(2):180-189 (2021) doi: 10.1093/carcin/bgaa131
  16. Ureshino H, Kurahashi Y, Watanabe T, Yamashita S, Kamachi K, Yamamoto Y, Fukuda-Kurahashi Y, Yoshida-Sakai N, Hattori N, Hayashi Y, Kawaguchi A, Tohyama K, Okada S, Harada H, Ushijima T, Kimura S. Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects. Mol Cancer Ther 20(8):1412-1421 (2021) doi: 10.1158/1535-7163.MCT-20-1125
  17. Nitani C, Hara J, Kawamoto H, Taguchi T, Kimura T, Yoshimura K, Hamada A, Kitano S, Hattori N, Ushijima T, Ono H, Nakamoto M, Higuchi T, Sato A. Phase I study of tamibarotene monotherapy in pediatric and young adult patients with recurrent/refractory solid tumors. Cancer Chemother Pharmacol 88(1):99-107 (2021) doi: 10.1007/s00280-021-04271-9
  18. Hattori N*, Asada K, Miyajima N, Mori A, Nakanishi Y, Kimura K, Wakabayashi M, Takeshima H, Nitani C, Hara J, Ushijima T*. Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming. Br J Cancer 125(12):1647-1656 (2021)(*Corresponding author) doi: 10.1038/s41416-021-01571-y
  19. Miyamoto T, Uosaki H, Mizunoe Y, Han SL, Goto S, Yamanaka D, Masuda M, Yoneyama Y, Nakamura H, Hattori N, Takeuchi Y, Ohno H, Sekiya M, Matsuzaka T, Hakuno F, Takahashi SI, Yahagi N, Ito K, Shimano H. Rapid manipulation of mitochondrial morphology in a living cell with iCMM. Cell Reports Methods,1(4):100052 (2021) doi.org/10.1016/j.crmeth.2021.100052
  20. Yamashita S, Hattori N, Fujii S, Yamaguchi T, Takahashi M, Hozumi Y, Kogawa T, El-Omar O, Liu YY, Arai N, Mori A, Higashimoto H, Ushijima T, Mukai H. Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy. Sci Rep 10(1):15530 (2020) doi: 10.1038/s41598-020-72661-9
  21. Watanabe T, Yamashita S, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Yoshida N, Hattori N, Nakamura H, Sato A, Kawaguchi A, Sueoka-Aragane N, Kojima K, Okada S, Ushijima T, Kimura S, Sueoka E. Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100. Blood 136(7):871-884 (2020) doi: 10.1182/blood.2019003084
  22. Wang H, Mizuno K, Takahashi N, Kobayashi E, Shirakawa J, Terauchi Y, Kasai H, Okunishi K, Izumi T. Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane. Diabetes 69(12):2655-2666 (2020) doi: 10.2337/db20-0069
  23. Takeshima H, Yoda Y, Wakabayashi M, Hattori N, Yamashita S, Ushijima T. Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level. Clin Epigenetics 12(1):142 (2020) doi: 10.1186/s13148-020-00937-y
  24. Okunishi K#*, Wang H#, Suzukawa M, Ishizaki R, Kobayashi E, Kihara M, Abe T, Miyazaki JI, Horie M, Saito A, Saito H, Nakae S, Izumi T*. Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses. J Clin Invest 130(7):3919-3935 (2020)(#Equally contributed)(*Corresponding author) doi: 10.1172/JCI127839
  25. Moro H, Hattori N, Nakamura Y, Kimura K, Imai T, Maeda M, Yashiro M, Ushijima T. Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways. Gastric Cancer 23(1):105-115 (2020) doi: 10.1007/s10120-019-01010-1
  26. Maeda M, Takeshima H, Iida N, Hattori N, Yamashita S, Moro H, Yasukawa Y, Nishiyama K, Hashimoto T, Sekine S, Ishii G, Ochiai A, Fukagawa T, Katai H, Sakai Y, Ushijima T. Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3. Gut 69(2):243-251 (2020) doi: 10.1136/gutjnl-2018-317645
  27. Ishihara H, Yamashita S, Liu YY, Hattori N, El-Omar O, Ikeda T, Fukuda H, Yoshida K, Takagi T, Taneda S, Kondo T, Nagashima Y, Tanabe K, Ushijima T. Genetic and epigenetic profiling indicates the proximal tubule origin of renal cancers in end-stage renal disease. Cancer Sci 111(11):4276-4287 (2020) doi: 10.1111/cas.14633
  28. Zong L#, Hattori N#, Yasukawa Y, Kimura K, Mori A, Seto Y, Ushijima T. LINC00162 confers sensitivity to 5-Aza-2′-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1. Oncogene 38(26):5281-5293 (2019)(#Equally contributed) doi: 10.1038/s41388-019-0792-8
  29. Hattori N, Sako M, Kimura K, Iida N, Takeshima H, Nakata Y, Kono Y, Ushijima T. Novel prodrugs of decitabine with greater metabolic stability and less toxicity. Clin Epigenetics 11(1):111 (2019) doi: 10.1186/s13148-019-0709-y
  30. Hattori N, Niwa T, Ishida T, Kobayashi K, Imai T, Mori A, Kimura K, Mori T, Asami Y, Ushijima T. Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model. Cancer Sci 110(1):147-156 (2019) doi: 10.1111/cas.13880
  31. Asano N, Takeshima H, Yamashita S, Takamatsu H, Hattori N, Kubo T, Yoshida A, Kobayashi E, Nakayama R, Matsumoto M, Nakamura M, Ichikawa H, Kawai A, Kondo T, Ushijima T. Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas. Sci Rep 9(1):20360 (2019) doi: 10.1038/s41598-019-56883-0
  32. Yamashita S, Kishino T, Takahashi T, Shimazu T, Charvat H, Kakugawa Y, Nakajima T, Lee YC, Iida N, Maeda M, Hattori N, Takeshima H, Nagano R, Oda I, Tsugane S, Wu MS, Ushijima T. Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues. Proc Natl Acad Sci U S A 115(6):1328-1333 (2018) doi: 10.1073/pnas.1717340115
  33. Okochi-Takada E, Hattori N, Ito A, Niwa T, Wakabayashi M, Kimura K, Yoshida M, Ushijima T. Establishment of a high-throughput detection system for DNA demethylating agents. Epigenetics 13(2):147-155 (2018) doi: 10.1080/15592294.2016.1267887
  34. Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, Yamamoto T, Sakuma T. Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays. CRISPR J 1(5):337-347 (2018) doi: 10.1089/crispr.2018.0009
  35. Hattori N, Ushijima T. Analysis of DNA Methylation in Tissues Exposed to Inflammation. Methods Mol Biol 1725(185-199 (2018) doi: 10.1007/978-1-4939-7568-6_16
  36. Bu Y, Okunishi K*, Yogosawa S, Mizuno K, Irudayam MJ, Brown CW, Izumi T*. Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages. Diabetes 67(9):1761-1772 (2018)(*Corresponding author) doi: 10.2337/db17-1201
  37. Yamashita S, Iida N, Takeshima H, Hattori N, Maeda M, Kishino T, Nagano R, Shimazu T, Tsugane S, Ushijima T. A novel method to quantify base substitution mutations at the 10(-6) per bp level in DNA samples. Cancer Lett 403(152-158 (2017) doi: 10.1016/j.canlet.2017.06.010
  38. Wettlaufer SH, Penke LR, Okunishi K, Peters-Golden M. Distinct PKA regulatory subunits mediate PGE(2) inhibition of TGFbeta-1-stimulated collagen I translation and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol 313(4):L722-L731 (2017) doi: 10.1152/ajplung.00131.2017
  39. Nakamura Y, Hattori N, Iida N, Yamashita S, Mori A, Kimura K, Yoshino T, Ushijima T. Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway. Cancer Lett 402(100-109 (2017) doi: 10.1016/j.canlet.2017.05.017
  40. Fan F, Matsunaga K, Wang H, Ishizaki R, Kobayashi E, Kiyonari H, Mukumoto Y, Okunishi K, Izumi T. Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. Elife 6((2017) doi: 10.7554/eLife.26174
  41. Zong L, Hattori N, Yoda Y, Yamashita S, Takeshima H, Takahashi T, Maeda M, Katai H, Nanjo S, Ando T, Seto Y, Ushijima T. Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer. Gastric Cancer 19(2):361-369 (2016) doi: 10.1007/s10120-015-0475-2
  42. Nakazato H, Takeshima H, Kishino T, Kubo E, Hattori N, Nakajima T, Yamashita S, Igaki H, Tachimori Y, Kuniyoshi Y, Ushijima T. Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis. PLoS One 11(1):e0147372 (2016) doi: 10.1371/journal.pone.0147372
  43. Wei FZ, Cao Z, Wang X, Wang H, Cai MY, Li T, Hattori N, Wang D, Du Y, Song B, Cao LL, Shen C, Wang L, Wang H, Yang Y, Xie D, Wang F, Ushijima T, Zhao Y, Zhu WG. Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway. Autophagy 11(12):2309-2322 (2015) doi: 10.1080/15548627.2015.1117734
  44. Takeshima H, Wakabayashi M, Hattori N, Yamashita S, Ushijima T. Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy. Carcinogenesis 36(2):192-201 (2015) doi: 10.1093/carcin/bgu238
  45. Zaslona Z, Okunishi K, Bourdonnay E, Domingo-Gonzalez R, Moore BB, Lukacs NW, Aronoff DM, Peters-Golden M. Prostaglandin E(2) suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. J Allergy Clin Immunol 133(2):379-387 (2014) doi: 10.1016/j.jaci.2013.07.037
  46. Okunishi K, DeGraaf AJ, Zaslona Z, Peters-Golden M. Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions. FASEB J 28(1):56-66 (2014) doi: 10.1096/fj.13-231720
  47. Okochi-Takada E, Hattori N, Tsukamoto T, Miyamoto K, Ando T, Ito S, Yamamura Y, Wakabayashi M, Nobeyama Y, Ushijima T. ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis. Oncogene 33(17):2273-2278 (2014) doi: 10.1038/onc.2013.174
  48. Liu Z, Zhang J, Gao Y, Pei L, Zhou J, Gu L, Zhang L, Zhu B, Hattori N, Ji J, Yuasa Y, Kim W, Ushijima T, Shi H, Deng D. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Clin Cancer Res 20(17):4598-4612 (2014) doi: 10.1158/1078-0432.CCR-13-3380
  49. Takahashi T, Matsuda Y, Yamashita S, Hattori N, Kushima R, Lee YC, Igaki H, Tachimori Y, Nagino M, Ushijima T. Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation. PLoS One 8(12):e82302 (2013) doi: 10.1371/journal.pone.0082302
  50. Hattori N, Niwa T, Kimura K, Helin K, Ushijima T. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res 41(15):7231-7239 (2013) doi: 10.1093/nar/gkt528
  51. Zasłona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M. Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood 119(10):2358-2367 (2012) doi: 10.1182/blood-2011-08-374207
  52. Okunishi K, Sisson TH, Huang SK, Hogaboam CM, Simon RH, Peters-Golden M. Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling. J Biol Chem 286(37):32231-32243 (2011) doi: 10.1074/jbc.M111.235606
  53. Hattori N, Okochi-Takada E, Kikuyama M, Wakabayashi M, Yamashita S, Ushijima T. Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. Cancer Sci 102(7):1337-1343 (2011) doi: 10.1111/j.1349-7006.2011.01955.x

  54. Bauman KA#, Wettlaufer SH#, Okunishi K#, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, Peters-Golden M. The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J Clin Invest 120(6):1950-1960 (2010)(#Equally contributed) doi: 10.1172/JCI38369 

  55. Okunishi K, Sasaki O, Okasora T, Nakagome K, Imamura M, Harada H, Matsumoto T, Tanaka R, Yamamoto K, Tabata Y, Dohi M. Intratracheal delivery of hepatocyte growth factor directly attenuates allergic airway inflammation in mice. Int Arch Allergy Immunol 149 Suppl 1(14-20 (2009) doi: 10.1159/000210648
  56. Okunishi K, Dohi M, Fujio K, Nakagome K, Tabata Y, Okasora T, Seki M, Shibuya M, Imamura M, Harada H, Tanaka R, Yamamoto K. Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice. J Immunol 179(8):5504-5513 (2007) doi: 10.4049/jimmunol.179.8.5504
  57. Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, Yagi S, Tanaka S, Shiota K. Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes Cells 12(3):387-396 (2007) doi: 10.1111/j.1365-2443.2007.01058.x
  58. Okunishi K, Dohi M, Nakagome K, Tanaka R, Mizuno S, Matsumoto K, Miyazaki J, Nakamura T, Yamamoto K. A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J Immunol 175(7):4745-4753 (2005) doi: 10.4049/jimmunol.175.7.4745
  59. Okunishi K, Dohi M, Nakagome K, Tanaka R, Yamamoto K. A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung. J Immunol 173(10):6393-6402 (2004) doi: 10.4049/jimmunol.173.10.6393
  60. Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, Shiota K. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem 279(17):17063-17069 (2004) doi: 10.1074/jbc.M309002200

主要総説Selected Reviews

  1. 服部奈緒子, 牛島俊和. DNAメチル化阻害剤. 遺伝子医学mook 36:196-203 (2021)
  2. 服部奈緒子, 牛島俊和. エピジェネティクス. 日本臨床（肉腫） 78:95-102 (2020)
  3. 服部奈緒子, 牛島俊和. DNA脱メチル化剤および変異型IDH阻害剤の臨床導入と新規開発の現状. 医学のあゆみ「エピジェネティクスと疾患」 272:106-114 (2020)
  4. 奥西勝秀, 泉哲郎. ALK7の肥満マウス白色脂肪織における生理的・病態生理的意義. 糖尿病・内分泌代謝科 51:298-303 (2020)
  5. 服部奈緒子, 牛島俊和. DNA脱メチル化剤の作用機序、臨床導入および新規開発の状況. 医学のあゆみ 266:823-829 (2018)
  6. Hattori N, Ushijima T. Epigenetic impact of infection on carcinogenesis: mechanisms and applications. Genome Med 8(1):10 (2016) doi: 10.1186/s13073-016-0267-2
  7. 服部奈緒子, 牛島俊和. エピゲノムを用いたがんの予後診断. 医学のあゆみ「クリニカルエピゲノミクス」255:629-635 (2016)
  8. Hattori N, Ushijima T. Compendium of aberrant DNA methylation and histone modifications in cancer. Biochem Biophys Res Commun 455(1-2):3-9 (2014) doi: 10.1016/j.bbrc.2014.08.140
  9. Ushijima T, Hattori N. Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers. Clin Cancer Res 18(4):923-929 (2012) doi: 10.1158/1078-0432.CCR-11-2011
  10. 服部奈緒子, 牛島俊和. がんのエピジェネティクス. チャイルドヘルス 15(3):33-37 (2012)
  11. Okunishi K, Peters-Golden M. Leukotrienes and airway inflammation. Biochim Biophys Acta 1810(11):1096-1102 (2011) doi: 10.1016/j.bbagen.2011.02.005
  12. 服部奈緒子, 牛島俊和.  発がんとエピジェネティクス　新たにわかったがんの原因とその治療の可能性. Biophilia 5:22-27 (2009)
  13. 服部奈緒子, 大鐘　潤, 塩田邦郎. エピジェネティクス. 化学と生物, 44:841-850 (2006)
  14. 奥西勝秀.  HGFによる樹状細胞に対する抑制作用. 臨床免疫 45:693-698 (2006)
  15. 奥西勝秀, 土肥眞. 樹状細胞と気管支喘息. アレルギー科 20:340-347 (2005)
  16. 服部奈緒子, 塩田邦郎. 発生・生殖とエピジェネティクス. 現代医療 35:977-984 (2003)

著書Selected Books

  1. 服部奈緒子　実験医学別冊「論文図表を読む作法」第2章-10 : Promoterアッセイ, 11 : Gel Shiftアッセイ. 羊土社 (2022)
  2. 服部奈緒子, 牛島俊和 実験医学別冊「エピジェネティクス実験スタンダード」　DNA脱メチル化剤とHDAC阻害剤の処理　羊土社 (2017)
  3. Hattori N, Ushijima T. Handbook of Epigenetics. Chapter 8 – Analysis of gene-specific DNA methylation. The New Molecular and Medical Genetics. (2011)
  4. Okunishi K, Peters-Golden M. Inflammation and Allergy Drug Design. Chapter 23 – Leukotrienes. pp285-295. Wiley-Blackwell. (2011)

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