Dysregulation of cell identity leads to disruption of homeostasis, becoming an underlying cause of disease development. We focus on epigenetics and immune cell signaling, which play crucial roles in cell fate determination, and aim to unravel the pathological mechanisms underlying various diseases, including diabetes, cancer, and allergies. Through an integrative analysis of molecules, cultured cells, and mouse models, we are investigating the molecular basis of disease onset and developing novel therapeutic strategies.

On-going projects

■ Identification of epigenome alterations involved in disease onset and development of epigenetic therapy
■ Regulation of drug sensitivity by fatty acid metabolism through alterations in cellular membrane composition
■ Clarification of novel mechanisms of allergic immune responses
■ Regulation of GDF3-ALK7 axis and fat accumulation by the immune system

Staff

• ProfessorHATTORI Naoko researchmapORCID ID
  
• Assistant ProfessorYAMAGISHI Genki researchmap　ORCID ID
• Technical officerTOBO Masayuki
• Technical AssistantIZAWA Yumi
• Undergraduate studentKASAHARA Fumika
• Undergraduate studentKIMURA Kozue

Former Colleagues

• • Associate ProfessorOKUNISHI Katsuhide (currently Professor, Faculty of Medicine, Toho University)
  • Technical AssistantSUDO Makoto
  • Technical AssistantTOZUKA Rina

Selected References

1. Okunishi K, et al. (2024) Allergy 79(7), 1992–1995. doi: 10.1111/all.16087.
2. Zhao M*, Okunishi K*, et al. (2023) JCI insight 8(4):e161229. doi: 10.1172/jci.insight.161229.
3. Hattori N, et al. (2021) Br J Cancer 125(12):1647-1656. doi: 10.1038/s41416-021-01571-y.
4. Okunishi K, et al. (2020) J Clin Invest 130(7):3919-3935. doi: 10.1172/JCI127839.
5. Zong L*, Hattori N*, et al. (2019) Oncogene 38(26):5281-5293. doi: 10.1038/s41388-019-0792-8.
6. Bu Y, Okunishi K, et al. (2018) Diabetes 67:1761-1772. doi: 10.2337/db17-1201.
7. Hattori N, et al (2013) Nucleic Acids Res 41:7231-7239. doi: 10.1093/nar/gkt528.